The California Department of Public Health (CDPH) developed a new framework (published on January 14, 2021) to support school communities as they decide when and how to implement in-person instruction for the 2020-2021 school year. This framework is an update to the COVID-19 and Reopening In-Person Learning Framework for K-12 Schools in California, 2020-2021 School Year (July 17, 2020) guidance. This update also impacts guidance in the COVID-19 Prepared: Reopening of Santa Clara County K-12 Schools (September 21, 2020).